Incidence of Precancerous Foci of Mammary Glands and Growth Rate of Transplantable Mammary Cancers in Sialoadenectomized Mice

Sialoadenectomies performed on 8-week-old female SHN and GR mice markedly reduced the numbers of precancerous and cancerous lesions in their mammary glands that had been mildly hypoplastic; the mice were necropsied when they were 30 weeks old. The success rate of the mammary cancer transplantation t...

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Published in:JNCI : Journal of the National Cancer Institute 1989-11, Vol.81 (21), p.1660-1663
Main Authors: Inui, Toshihiko, Tsubura, Airo, Morii, Sotokichi
Format: Article
Language:English
Subjects:
Animals
Epidermal Growth Factor - physiology
Female
Male
Mammary Neoplasms, Experimental - etiology
Mammary Neoplasms, Experimental - pathology
Mice
Mice, Inbred C3H
Neoplasm Transplantation
Precancerous Conditions - etiology
Submandibular Gland - physiology
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container_title JNCI : Journal of the National Cancer Institute
container_volume 81
creator Inui, Toshihiko
Tsubura, Airo
Morii, Sotokichi
description Sialoadenectomies performed on 8-week-old female SHN and GR mice markedly reduced the numbers of precancerous and cancerous lesions in their mammary glands that had been mildly hypoplastic; the mice were necropsied when they were 30 weeks old. The success rate of the mammary cancer transplantation to isogenic male SHN or C3H mice was lower in the sialoadenectomized animals, and growth of the grafted tumors was delayed after gland removal. Some tumor development resumed in the hosts that received mouse epidermal growth factor after surgery. Therefore, we believe this growth factor may play a role in the multistage process of mouse mammary carcinogenesis. [J Natl Cancer Inst 81:1660–1663, 1989]
doi_str_mv 10.1093/jnci/81.21.1660
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source Oxford University Press Archive
subjects Animals
Epidermal Growth Factor - physiology
Female
Male
Mammary Neoplasms, Experimental - etiology
Mammary Neoplasms, Experimental - pathology
Mice
Mice, Inbred C3H
Neoplasm Transplantation
Precancerous Conditions - etiology
Submandibular Gland - physiology
title Incidence of Precancerous Foci of Mammary Glands and Growth Rate of Transplantable Mammary Cancers in Sialoadenectomized Mice
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