The Impact on Health-Related Quality of Life from Non-Steroidal Anti-Inflammatory Drugs, Methotrexate, or Steroids in Treatment for Juvenile Idiopathic Arthritis

Objective To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and pla...

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Bibliographic Details
Published in:Journal of pediatric psychology 2006-04, Vol.31 (3), p.262-271
Main Authors: Riddle, Russ, Ryser, Christina N., Morton, Anne A., Sampson, J. D., Browne, Richard H., Punaro, Marilynn G., Gatchel, Robert J.
Format: Article
Language:English
Subjects:
Adolescent
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antirheumatic Agents - adverse effects
Antirheumatic Agents - therapeutic use
Arthritis, Juvenile - drug therapy
Biological and medical sciences
Child
Child clinical studies
Child, Preschool
Diseases of the osteoarticular system
Female
Follow-Up Studies
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Health Status
health-related quality of life
Humans
Infant
Inflammatory joint diseases
juvenile arthritis
Male
Medical sciences
Methotrexate - adverse effects
Methotrexate - therapeutic use
Methylprednisolone - adverse effects
Methylprednisolone - therapeutic use
Multivariate Analysis
outcomes
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Quality of Life
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Summary:Objective To assess and compare the impact of medication treatments on health-related quality of life (HRQOL), family function, and medical status in children with juvenile idiopathic arthritis (JIA). Methods Fifty-seven children diagnosed with JIA were assessed by a pediatric rheumatologist and placed into one of three treatment groups: (1) non-steroidal anti-inflammatory; (2) methotrexate; or (3) steroids via IV methylprednisolone. Questionnaires were administered at baseline and 4-month follow-up. The attending pediatric rheumatologist provided additional medical information. Results Data document the impact of JIA on HRQOL, particularly on physical and pain domains. Steroid patients experienced improved HRQOL at follow-up relative to other groups, despite reporting more problems with side effects. Conclusion These results demonstrate positive benefits of steroids in treating JIA children, despite the greatest incidence of adverse side effects.
ISSN:0146-8693
1465-735X
DOI:10.1093/jpepsy/jsj014