Structure and properties of carbocyclic 5′-Nor oligodeoxynucleotides

The hybridization properties of carbocyclic 5′-nor oligodeoxynucleotides 1, 2 (24 mer, B= A) with DNA and RNA were investigated by CD melting curves. These oligomers formed unstable duplexes with DNA, but formed stable duplexes with RNA selectively.

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Bibliographic Details
Published in:Nucleic Acids Symposium Series 2001-11, Vol.1 (1), p.19-20
Main Authors: Koga, Masakazu, Tamai, Koichi, Ueda, Mitsunori, Uchida, Toshinori, Yamamuro, Toshiyuki, Suzuki, Takaaki, Saeki, Toshiaki
Format: Article
Language:English
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Summary:The hybridization properties of carbocyclic 5′-nor oligodeoxynucleotides 1, 2 (24 mer, B= A) with DNA and RNA were investigated by CD melting curves. These oligomers formed unstable duplexes with DNA, but formed stable duplexes with RNA selectively.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/1.1.19