Synthesis of noraristeromycin analogues possessing SAH hydrolase inhibitory activity for the development of antimalaria agents

Noraristeromycin analogues such as 3′, 4′ -anhydronoraristeromycins, 2-amino-3′, 4′-anhydronoraristeromycin and N6-cyclopropyl-noraristeromycin were synthesized and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolase was investigated. Among the...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Symposium Series 2002-11, Vol.2 (1), p.141-142
Main Authors: Kojima, Hiroharu, Yamaguchi, Tsuyoshi, Kozaki, Atsushi, Nakanishi, Masayuki, Ueno, Yoshihito, Kitade, Yukio
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Noraristeromycin analogues such as 3′, 4′ -anhydronoraristeromycins, 2-amino-3′, 4′-anhydronoraristeromycin and N6-cyclopropyl-noraristeromycin were synthesized and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolase was investigated. Among them, 3′, 4′-anhydronoraristeromycin showed inhibitory activity against human recombinant S-adenosyl-L-homocysteine hydrolase (Ki = 12.4 μM, Kinact = 0.55 min−1).
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/2.1.141