Artificial metallo-DNA: structural control and discrete metal assembly

To array Cu2+ ions within a double-stranded DNA along the helix axis in a controllable manner, a series of artificial oligonucleotides, d(5′-GHnC-3′) (n = 1-5), were synthesized, where H is a hydroxypyridone nucleobase. Right-handed double helices of the oligonucleotides, nCu2+·d(5′-GHnC-3′)2 (n = 1...

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Bibliographic Details
Published in:Nucleic Acids Symposium Series 2003-09, Vol.3 (1), p.121-122
Main Authors: Tanaka, Kentaro, Yamada, Yasuyuki, Tengeiji, Atsushi, Kato, Tatsuhisa, Toyama, Namiki, Takezawa, Yusuke, Yori, Maiko, Shiro, Motoo, Shionoya, Mitsuhiko
Format: Article
Language:English
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Summary:To array Cu2+ ions within a double-stranded DNA along the helix axis in a controllable manner, a series of artificial oligonucleotides, d(5′-GHnC-3′) (n = 1-5), were synthesized, where H is a hydroxypyridone nucleobase. Right-handed double helices of the oligonucleotides, nCu2+·d(5′-GHnC-3′)2 (n = 1-5), were quantitatively formed through Cu2+-mediated metallo-base pairing (H-Cu2+-H). The Cu2+ ions incorporated into each duplex were aligned along the helix axes with the Cu2+-Cu2+ distance of 3.7 ± 0.1 Å. The unpaired d electrons of the Cu2+ ions were coupled ferromagnetically with one another to form magnetic chains.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/3.1.121