The synthesis of pyrrole(Py)/imidazole(lm) polyamide CPI conjugates which possess DNA interstrand cross-linking activity

Covalent dimers of ImPyLDu86 with various linkers were synthesized and their DNA interstrand cross-linking abilities were examined. Denaturing polyacrylamide gel electrophoresis indicated that dimer molecule with tetramethylene linker efficiently produced interstrand cross-link only in the presence...

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Bibliographic Details
Published in:Nucleic Acids Symposium Series 2000-10, Vol.44 (1), p.45-46
Main Authors: Bando, Toshikazu, lida, Hirokazu, Saito, Isao, Sugiyama, Hiroshi
Format: Article
Language:English
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Summary:Covalent dimers of ImPyLDu86 with various linkers were synthesized and their DNA interstrand cross-linking abilities were examined. Denaturing polyacrylamide gel electrophoresis indicated that dimer molecule with tetramethylene linker efficiently produced interstrand cross-link only in the presence of appropriate partner PyIm triamides.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/44.1.45