Biochemical dissection of RISC assembly and function

Abstract Small silencing RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs), regulate expression of their target genes via RNA-induced silencing complex (RISC). RISC assembly follows complex, ordered pathways, and RISC function is as diverse as cleavage, translational repression,...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Symposium Series 2009-09, Vol.53 (1), p.15-15
Main Author: Tomari, Yukihide
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Small silencing RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs), regulate expression of their target genes via RNA-induced silencing complex (RISC). RISC assembly follows complex, ordered pathways, and RISC function is as diverse as cleavage, translational repression, and deadenylation of the target. We have recently shown how siRNAs and miRNAs are assembled into distinct types of RISC, and how differently they function, using Drosophila as a model organism.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/nrp008