Contrasting renal effects of nicotine in smokers and non-smokers

Cigarette smoking is associated with acute increase in arterial pressure due to systemic vasoconstriction and decreased skin and coronary blood flow. Virtually all cardiovascular effects of cigarette smoking are due to nicotine. However, whether nicotine also affects the renal circulation and functi...

Full description

Saved in:
Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1998-04, Vol.13 (4), p.940-944
Main Authors: HALIMI, J.-M, PHILIPPON, C, MIMRAN, A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cyclic GMP - urine
Female
Hemodynamics - drug effects
Humans
Kidney - drug effects
Male
Medical sciences
Nicotine - toxicity
Renin - blood
Smoking - physiopathology
Tobacco, tobacco smoking
Toxicology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cigarette smoking is associated with acute increase in arterial pressure due to systemic vasoconstriction and decreased skin and coronary blood flow. Virtually all cardiovascular effects of cigarette smoking are due to nicotine. However, whether nicotine also affects the renal circulation and function in humans is at present unknown. In the current study the acute effects of a 4-mg nicotine gum on arterial pressure, heart rate as well as renal haemodynamics and function were assessed in non-smokers and chronic smokers. In non-smokers, mean arterial pressure (+8 +/- 1 mmHg, P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/13.4.940