Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells

Background. Rosmarinic acid is a phenolic compound widely distributed in Labiatae herbs such as rosemary, sweet basil, and perilla, which are frequently used with meat and fish dishes in Western and Asian countries. In the present study we investigated the effects of rosmarinic acid on cultured muri...

Full description

Saved in:
Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2000-08, Vol.15 (8), p.1140-1145
Main Authors: Makino, Toshiaki, Ono, Takahiko, Muso, Eri, Yoshida, Haruyoshi, Honda, Gisho, Sasayama, Shigetake
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Cell Cycle - drug effects
Cell Division - drug effects
Cell Survival - drug effects
Cells, Cultured
Cinnamates - pharmacology
Depsides
Female
Glomerular Mesangium - cytology
Glomerular Mesangium - metabolism
Glomerular Mesangium - physiology
glomerulonephritis
Investigative techniques, diagnostic techniques (general aspects)
Labiatae herbs
Medical sciences
mesangial cell proliferation
Mice
Mice, Inbred BALB C
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Platelet-Derived Growth Factor - genetics
Proto-Oncogene Proteins c-myc - genetics
RNA, Messenger - metabolism
Rosmarinic Acid
Urinary system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Rosmarinic acid is a phenolic compound widely distributed in Labiatae herbs such as rosemary, sweet basil, and perilla, which are frequently used with meat and fish dishes in Western and Asian countries. In the present study we investigated the effects of rosmarinic acid on cultured murine mesangial cell proliferation. Methods. Cultured murine mesangial cells were stimulated by growth factors with or without rosmarinic acid, and [3H]thymidine incorporation was measured in regard both to signal transduction and to cell cycle dependency. In other experiments, mRNA extracted from the cells was analysed by Northern blotting. Results. Rosmarinic acid inhibited the cell proliferation induced by platelet‐derived growth factor (PDGF) (P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/15.8.1140