Association between the fatty liver index and chronic kidney disease: the population-based KORA study

ABSTRACT Background We aimed to evaluate the relationship of fatty liver, estimated by the fatty liver index (FLI), with kidney function and chronic kidney disease (CKD) in a German cohort study, given the lack of prospective evidence in Europeans. Methods We included 2920 participants (51.6% women,...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2023-05, Vol.38 (5), p.1240-1248
Main Authors: Cai, Xinting, Thorand, Barbara, Hohenester, Simon, Koenig, Wolfgang, Rathmann, Wolfgang, Peters, Annette, Nano, Jana
Format: Article
Language:English
Subjects:
Aged
Cardiometabolic Risk Factors
Creatinine
Cystatins
Fatty Liver - epidemiology
Female
Germany
Glomerular Filtration Rate
Humans
Kidney - physiology
Male
Middle Aged
Population Surveillance
Prevalence
Prospective Studies
Renal Insufficiency, Chronic - epidemiology
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Summary:ABSTRACT Background We aimed to evaluate the relationship of fatty liver, estimated by the fatty liver index (FLI), with kidney function and chronic kidney disease (CKD) in a German cohort study, given the lack of prospective evidence in Europeans. Methods We included 2920 participants (51.6% women, mean age 56.1 years) from the KORA study, of which 1991 were followed up for an average of 6.5 years (± 0.3). Kidney function was assessed using the glomerular filtration rate estimated by creatinine (eGFR-Cr) or cystatin C (eGFR-cC). We used multiple logistic or linear regressions to evaluate the associations between the FLI, kidney function and CKD (eGFR 
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfac266