Incidence of polyomavirus‐nephropathy in renal allografts: influence of modern immunosuppressive drugs

Background. In recent years an increasing number of cases with polyomavirus (PV)‐nephropathy after renal transplantation were reported from several transplant centres. New, highly potent immunosuppressive drugs like tacrolimus or mycophenolate mofetil were accused as risk factors for this increase....

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2003-06, Vol.18 (6), p.1190-1196
Main Authors: Mengel, Michael, Marwedel, Magali, Radermacher, Jörg, Eden, Gabriele, Schwarz, Anke, Haller, Hermann, Kreipe, Hans
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Child
Child, Preschool
Drug Therapy, Combination
Emergency and intensive care: renal failure. Dialysis management
Female
Graft Rejection - pathology
Graft Rejection - prevention & control
Graft Rejection - virology
Graft Survival
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Intensive care medicine
Kidney Failure, Chronic - surgery
Kidney Transplantation
Male
Medical sciences
Middle Aged
Mycophenolic Acid - adverse effects
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Polyomavirus
Polyomavirus Infections - etiology
Prospective Studies
renal transplantation
Risk Factors
Tacrolimus - adverse effects
Tacrolimus - therapeutic use
Tumor Virus Infections - etiology
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Summary:Background. In recent years an increasing number of cases with polyomavirus (PV)‐nephropathy after renal transplantation were reported from several transplant centres. New, highly potent immunosuppressive drugs like tacrolimus or mycophenolate mofetil were accused as risk factors for this increase. However, data about the incidence of PV‐nephropathy in correlation to different immunosuppressive therapy concepts are lacking. Methods. All renal transplant biopsies performed at Hannover Medical School between 1999 and 2001 (n=1276) were immunohistochemically screened for the presence of PV‐specific proteins. The results were correlated to the different immunosuppressive therapy protocols and patients with PV‐nephropathy were compared with a matched control group. Results. PV‐nephropathy was found in
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfg072