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P11.06.A NEUROPLASTIC CHANGES IN VISUAL NETWORK CONNECTIVITY AND VISUAL COGNITIVE FUNCTIONING IN BRAIN TUMOR PATIENTS WITH LESIONS IN THE OPTIC RADIATION

Abstract BACKGROUND The influence of brain tumors along important structures of the visual pathway on the overall organization of the visual system and visual cognitive functioning is not fully understood. To address this, the influence of a brain tumor infiltrating the optic radiation (OR) on the f...

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Bibliographic Details
Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2024-10, Vol.26 (Supplement_5), p.v63-v63
Main Authors: Rosengarth, K, Hense, K, Deuter, D, Bumes, E, Lenglinger, M, Doenitz, C, Hau, P, Schmidt, N
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract BACKGROUND The influence of brain tumors along important structures of the visual pathway on the overall organization of the visual system and visual cognitive functioning is not fully understood. To address this, the influence of a brain tumor infiltrating the optic radiation (OR) on the functional connectivity in the visual network and on specific visual cognitive functions was investigated. MATERIAL AND METHODS fMRI data of 145 patients (69 female, M = 54.15 y) with brain tumors (96 left hemisphere, 49 right hemisphere) were included in this study. Patients were either assigned to a group with tumors inside (69 patients) or outside (76 patients) the area of the OR. A word generation task served as fMRI paradigm, as this reliably addresses the visual system through the visual presentation of stimuli in written form. Based on these data, seed-to-voxel functional connectivity was calculated using the CONN toolbox. Seed regions of interest were located in the bilateral calcarine cortex (CC), occipital poles (OP), and lateral occipital cortex (LOC). Neuropsychological testing included Rey-Osterrieth Complex Figure - Copy and 30min Recall, Trail Making Test A and Digit Symbol Coding, and Corsi Block Span task. RESULTS The results showed that patients with tumors distant from the OR had significant higher connectivity regarding all four ROIs compared to patients with tumors located in the projection zone of the OR. Significant connectivity clusters included parts of the left planum temporal, Heschl’s gyrus, parietal operculum, and central opercular cortex for the CC (p =.013), OP (p
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noae144.208