Real-World Experience with Higher-Than-Recommended Doses of Lamivudine in Patients with Varying Degrees of Renal Impairment

Abstract Background Lamivudine (3TC) renal dose-adjustment recommendations are based on pharmacokinetic modeling studies with small samples. Practice guidelines state that because of the favorable safety profile, in order to avoid using the liquid formulation of 3TC, using the lowest available table...

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Bibliographic Details
Published in:Open forum infectious diseases 2017-10, Vol.4 (suppl_1), p.S219-S220
Main Authors: Luteran, Briann, Cha, Agnes, Shah, Kushal, Taft, David, Bakshi, Anjali, Berkowitz, Leonard
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract Background Lamivudine (3TC) renal dose-adjustment recommendations are based on pharmacokinetic modeling studies with small samples. Practice guidelines state that because of the favorable safety profile, in order to avoid using the liquid formulation of 3TC, using the lowest available tablet strength of 100mg or 150mg in patients with advanced kidney disease may be considered. Despite the use of higher-than-recommended 3TC doses in HIV care, evidence is lacking to support the safety of this practice in the real-world setting. The practice at our institution does not dose-adjust 3TC until CrCl is 50 5 2930 3855 38440 30–49 16 3283 3994 47663 15-29 4 2395 4591 77340
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofx163.449