Lactose Absorption in Patients with Ovarian Cancer

To determine whether lactase persistence might be related to ovarian cancer risk, in 1994–1995 the authors assessed the capacity to digest lactose by measuring breath hydrogen production after oral administration of lactose in 50 women with ovarian cancer and 100 healthy controls. All of the women c...

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Bibliographic Details
Published in:American journal of epidemiology 1999-07, Vol.150 (2), p.183-186
Main Authors: Meloni, Gian Franco, Colombo, Carla, Vecchia, Carlo La, Ruggiu, Giuseppina, Mannazzu, Maria Chiara, Ambrosini, Guido, Cherchi, Pier Luigi
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Aged
Analysis. Health state
Biological and medical sciences
Breath Tests - methods
Carcinoma - chemically induced
Carcinoma - metabolism
Case-Control Studies
dairy products
Epidemiology
Female
Female genital diseases
galactose
General aspects
Gynecology. Andrology. Obstetrics
Humans
Hydrogen - metabolism
Intestinal Absorption
Italy - epidemiology
lactose
Lactose - administration & dosage
Lactose - adverse effects
Lactose - metabolism
Lactose Intolerance - epidemiology
Lactose Intolerance - metabolism
Medical sciences
Middle Aged
milk
ovarian neoplasms
Ovarian Neoplasms - chemically induced
Ovarian Neoplasms - metabolism
Public health. Hygiene
Public health. Hygiene-occupational medicine
Tumors
Citations: Items that cite this one
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Summary:To determine whether lactase persistence might be related to ovarian cancer risk, in 1994–1995 the authors assessed the capacity to digest lactose by measuring breath hydrogen production after oral administration of lactose in 50 women with ovarian cancer and 100 healthy controls. All of the women came from Sassari (Sardinia), Italy, an area where the population has a high frequency of lactose malabsorption. Thirty percent of cases were lactose absorbers, as compared with 15% of controls. The odds ratio for ovarian cancer among lactose absorbers was 2.51 (95% confidence interval 1.10–5.68). These results provide some support for a role of lactose ingestion and galactose cytotoxicity in the pathogenesis of ovarian cancer. Am J Epidemiol 1999;150:183–6.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a009978