EXPERIMENTAL INFECTION OF MONKEYS WITH LANGAT VIRUS

Spider monkeys regularly developed infection when large doses (1011 LD50) of Langat virus were administered orally, but were irregularly infected when the same dose was administered by stomach tube. A smaller (105 LD50) virus inoculum did not infect all monkeys when given by the oral route, but did...

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Bibliographic Details
Published in:American journal of epidemiology 1969-04, Vol.89 (4), p.480-488
Main Authors: NATHANSON, NEAL, COLE, GERALD A., HODOUS, JOHN
Format: Article
Language:English
Subjects:
arbovirus
encephalitis virus
Langat
monkey
oral and fecal
spider (genus Ateles)
tick-borne complex
viremia
virus excretion
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Summary:Spider monkeys regularly developed infection when large doses (1011 LD50) of Langat virus were administered orally, but were irregularly infected when the same dose was administered by stomach tube. A smaller (105 LD50) virus inoculum did not infect all monkeys when given by the oral route, but did infect all monkeys when injected subcutaneously. The majority of both enteric and parenteral infections were accompanied by viremia and pharyngeal excretion, but virus was never isolated from the stool.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a120960