CELLULAR INTERACTIONS BETWEEN LEAD AND CALCIUM

Lead ions (Pb2+) antagonise the action of Ca2+ ions at many sites, and also mimic many of the biological effects of Ca2+ ions. These interactions are discussed, and related to the chemical differences between Pb2+ and Ca2+ ions. Lead has many effects that are entirely unlike those of calcium, so the...

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Bibliographic Details
Published in:British medical bulletin 1986, Vol.42 (4), p.431-434
Main Author: SIMONS, T. J. B
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - antagonists & inhibitors
Calcium - metabolism
Cattle
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Phenomena
Chemistry
Drug Interactions
Lead - metabolism
Medical sciences
Metals and various inorganic compounds
Toxicology
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Summary:Lead ions (Pb2+) antagonise the action of Ca2+ ions at many sites, and also mimic many of the biological effects of Ca2+ ions. These interactions are discussed, and related to the chemical differences between Pb2+ and Ca2+ ions. Lead has many effects that are entirely unlike those of calcium, so the toxicology of Pb cannot be explained solely by its interaction with Ca.
ISSN:0007-1420
1471-8391
DOI:10.1093/oxfordjournals.bmb.a072162