Evaluation of coronary flow reserve using myocardial contrast echocardiography in humans

To evaluate the applicability of myocardial contrast echocardiography for the assessment of coronary blood flow reserve, 21 consecutive patients undergoing coronary angiography were studied. Only patients with a single left anterior descending lesion or normal coronary angiogram were included. Intra...

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Bibliographic Details
Published in:European heart journal 1992-03, Vol.13 (3), p.389-394
Main Authors: REISNER, S. A., ONG, L. S., FITZPATRICK, P. G., LICHTENBERG, G. S., SULLEBARGER, J. T., ALLEN, M. N., MELTZER, R. S.
Format: Article
Language:English
Subjects:
Aged
Albumins
Biological and medical sciences
contrast echocardiography
Contrast Media
Coronary Angiography
Coronary Circulation - drug effects
Coronary Disease - diagnostic imaging
Coronary Disease - physiopathology
coronary low reserve
Echocardiography
Echocardiography - methods
Evaluation Studies as Topic
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Papaverine - adverse effects
Papaverine - pharmacology
Ultrasonic investigative techniques
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Summary:To evaluate the applicability of myocardial contrast echocardiography for the assessment of coronary blood flow reserve, 21 consecutive patients undergoing coronary angiography were studied. Only patients with a single left anterior descending lesion or normal coronary angiogram were included. Intracoronary injections of sonicated albumin were performed before and after the administration of intracoronary papa verine. Good quality studies at baseline and after the administration of papaverine were obtained in 14 of 21 patients. Ten patients had a signficant (>75%) single left anterior descending lesion amd four had normal or insignificant lesions (70% or less stenosis) in the left anterior descending coronary artery. Time-intensity curves for the left anterior descending coronary artery region of interest were generated and then the peak contrast intensity (PCI), washout half-time (T1/2) and the area under the curve (AUC) were calculated. The post-papaverine increases in PCI a.nd in the AUC, compared to baseline, were 55 ± 22% and 102 ± 14% in the four patients with 70% or less left anterior descending diameter stenosis serving as a control group and 3 ± 25% and 40 ± 10%, respectively, in the 10 patients with significant left anterior descending coronary artery disease (mean ± 1 SD, P
ISSN:0195-668X
1522-9645
DOI:10.1093/oxfordjournals.eurheartj.a060179