Antiarrhythmic efficacy of combined intravenous and oral mexiletine in acute myocardial infarction. A double blind placebo-controlled study

The antiarrhythmic efficacy of mexiletine in acute myocardial infarction (AMI) was studied in 99 patients randomized to mexiletine or placebo treatment. The loading dose was 250 mg i.v. and 400 mg orally followed by 200 mg orally 2 h later, and thereafter 200 mg t.i.d. up to 42 h. Arrhythmias occurr...

Full description

Saved in:
Bibliographic Details
Published in:European heart journal 1984-08, Vol.5 (8), p.675-683
Main Authors: HALINEN, M. O., PENTIKÄINEN, P. J., HELIN, M. J., REHNBERG, S.
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Adult
antiarrhythmic agents
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - prevention & control
Clinical Trials as Topic
continuous ECG recording
Double-Blind Method
Electrocardiography
Female
Humans
Male
mexiletine
Mexiletine - administration & dosage
Mexiletine - therapeutic use
Mexiletine - toxicity
Middle Aged
Monitoring, Physiologic
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Propylamines - administration & dosage
Random Allocation
Time Factors
ventricular arrhythmias
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The antiarrhythmic efficacy of mexiletine in acute myocardial infarction (AMI) was studied in 99 patients randomized to mexiletine or placebo treatment. The loading dose was 250 mg i.v. and 400 mg orally followed by 200 mg orally 2 h later, and thereafter 200 mg t.i.d. up to 42 h. Arrhythmias occurring during 48 h were analysed from continuous electrocardiographic recordings. AMI was verified in 35 of 50 mexiletine patients and in 38 of 49 placebo patients. No deaths or instances of ventricular fibrillation occurred in the AMI patients. The number of patients who had any event of accelerated idioventricular rhythm (AIVR; P
ISSN:0195-668X
1522-9645
DOI:10.1093/oxfordjournals.eurheartj.a061725