In-vitro fertilization and embryo transfer: a collaborative study of 1163 pregnancies on the incidence and risk factors of ectopic pregnancies

In a multi-centric study undertaken on 1163 pregnancies obtained by in-vitro fertilization, a 5% risk of ectopic pregnancies was observed. This figure is certainly higher than that admitted for natural reproduction. After simultaneous adjusting for all variables in our data by means of a multiple lo...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1986-06, Vol.1 (4), p.255-258
Main Authors: Cohen, Jean, Mayaux, Marie-Jeanne, Guihard-Mascato, Marie-Luce, Schwartz, Daniel
Format: Article
Language:English
Subjects:
Clomiphene - adverse effects
Embryo Transfer
Fallopian Tubes - physiology
Female
Fertilization in Vitro
Humans
Pregnancy
Pregnancy, Ectopic - etiology
Risk
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Summary:In a multi-centric study undertaken on 1163 pregnancies obtained by in-vitro fertilization, a 5% risk of ectopic pregnancies was observed. This figure is certainly higher than that admitted for natural reproduction. After simultaneous adjusting for all variables in our data by means of a multiple logistic regression technique, two factors have specific influence: the therapeutic use of clomiphene citrate which increased the rate of ectopic pregnancies from 3 to 6% and the number of patent Fallopian tubes with a change in ectopic pregnancies rate from 3 or 4% (with 0 or 2 patent tubes) to 13% (with one patent tube). These results suggest various physiologic hypotheses as well as therapeutic considerations.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a136396