Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect

The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, c...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1994-01, Vol.9 (1), p.57-63
Main Authors: Swahn, Marja-Liisa, Kovács, László, Cekan, Sten Z., Aedo, Ana-Rosa, Westlund, Pär
Format: Article
Language:English
Subjects:
abortion
Abortion, Therapeutic - methods
Adolescent
Adult
antigestagen
Biological and medical sciences
Birth control
Estrenes - adverse effects
Estrenes - pharmacokinetics
Estrenes - therapeutic use
Female
Gynecology. Andrology. Obstetrics
Hormones - blood
Humans
Induced abortion. Therapeutic abortion
Medical sciences
Nausea - chemically induced
Pregnancy
Pregnancy Trimester, First
Progestins - antagonists & inhibitors
Treatment Outcome
Uterine Hemorrhage - chemically induced
ZK 98
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Summary:The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, concomitant with less antiglucocorticoid activity. The aim of the present two-centre study was to explore the abortifacient efficacy and plasma concentrations of ZK 98, 734 in women seeking abortion. A total of 96 pregnant women with amenorrhoea of
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a138320