Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect

The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, c...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 1994-01, Vol.9 (1), p.57-63
Main Authors: Swahn, Marja-Liisa, Kovács, László, Cekan, Sten Z., Aedo, Ana-Rosa, Westlund, Pär
Format: Article
Language:English
Subjects:
abortion
Abortion, Therapeutic - methods
Adolescent
Adult
antigestagen
Biological and medical sciences
Birth control
Estrenes - adverse effects
Estrenes - pharmacokinetics
Estrenes - therapeutic use
Female
Gynecology. Andrology. Obstetrics
Hormones - blood
Humans
Induced abortion. Therapeutic abortion
Medical sciences
Nausea - chemically induced
Pregnancy
Pregnancy Trimester, First
Progestins - antagonists & inhibitors
Treatment Outcome
Uterine Hemorrhage - chemically induced
ZK 98
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c387t-e62f7354bf37387fd5e0dad849578017f3cd18615ca816579f3c72d1a5a9a3953
cites
container_end_page 63
container_issue 1
container_start_page 57
container_title Human reproduction (Oxford)
container_volume 9
creator Swahn, Marja-Liisa
Kovács, László
Cekan, Sten Z.
Aedo, Ana-Rosa
Westlund, Pär
description The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, concomitant with less antiglucocorticoid activity. The aim of the present two-centre study was to explore the abortifacient efficacy and plasma concentrations of ZK 98, 734 in women seeking abortion. A total of 96 pregnant women with amenorrhoea of
doi_str_mv 10.1093/oxfordjournals.humrep.a138320
format article
fullrecord <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1093_oxfordjournals_humrep_a138320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_HXZ_7JVWKRKG_T</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-e62f7354bf37387fd5e0dad849578017f3cd18615ca816579f3c72d1a5a9a3953</originalsourceid><addsrcrecordid>eNpVkFtLAzEQhYMotVZ_gpAHfXNrsmk2WcEHEa3agiD1QkHCNJvYtN0L2a22_95IS8GnDHPOCWc-hM4p6VKSsstyZUufzcqlL2BRd6fL3JuqC5RJFpM91Ka9hEQx42QftUmcyIjShB6io7qeERJGmbRQS9KUMx630efI-NwV0LiywKXFBvxijStvvgoo9Br_uGaKxwOcygssWO8KV1PwOehy7grTOI0nZgrfLrTBUGRYL1zhNCywsdbo5hgd2FDSnGzfDnq9vxvdPkTD5_7j7c0w0kyKJjJJbAXjvYllIixsxg3JIJO9lAtJqLBMZ6E35RokTbhIw0LEGQUOKbBwSQddb_7Vvqxrb6yqvMvBrxUl6o-a-k9NbaipLbWQP93kq-UkN9kuvcUU9LOtDnW4zvrAxtU7G0upFJQGW7Sxuboxq50Mfq4SwQRXDx9jJZ7e3gcvg74asV_EeIy9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect</title><source>Oxford University Press Archive</source><creator>Swahn, Marja-Liisa ; Kovács, László ; Cekan, Sten Z. ; Aedo, Ana-Rosa ; Westlund, Pär</creator><creatorcontrib>Swahn, Marja-Liisa ; Kovács, László ; Cekan, Sten Z. ; Aedo, Ana-Rosa ; Westlund, Pär</creatorcontrib><description>The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, concomitant with less antiglucocorticoid activity. The aim of the present two-centre study was to explore the abortifacient efficacy and plasma concentrations of ZK 98, 734 in women seeking abortion. A total of 96 pregnant women with amenorrhoea of &lt;49 days were treated with oral doses of 12.5, 25, 50 or 100 mg ZK 98, 734 twice daily for 4 days. The overall rate of complete abortion and continuing live pregnancies was 68 and 20% respectively, i.e. results comparable with treatment with mifepristone alone. No dose-response relationship was noted. In patients with complete abortion, signs of luteal sysfunction in terms of oestradiol and progesterone production were evident on the fourth treatment day, in contrast to patients with failures. Increased amounts of cortisol and prolactin were found during treatment both in successfully treated patients and failures, whereas aldosterone values remained unaffected. The effect on cortisol may indicate some antiglucocorticoid activity in the human. The concentrations of ZK 98, 734 in peripheral blood after 25, 50 and 100 mg twice daily for 4 days were similar. The values were slightly above 0.5μmol/l on the second day of treatment. Maximal concentrations of 0.7 μmol/l were seen on treatment day 4. Plasma concentrations of ZK 98, 734 did not differ in cases of complete abortion and failures. In conclusion, the abortifacient efficacy in relation to dose of the new antigestaged ZK 98, 734 does not essentially differ from that of mifepristone treatment alone.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/oxfordjournals.humrep.a138320</identifier><identifier>PMID: 8195352</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>abortion ; Abortion, Therapeutic - methods ; Adolescent ; Adult ; antigestagen ; Biological and medical sciences ; Birth control ; Estrenes - adverse effects ; Estrenes - pharmacokinetics ; Estrenes - therapeutic use ; Female ; Gynecology. Andrology. Obstetrics ; Hormones - blood ; Humans ; Induced abortion. Therapeutic abortion ; Medical sciences ; Nausea - chemically induced ; Pregnancy ; Pregnancy Trimester, First ; Progestins - antagonists &amp; inhibitors ; Treatment Outcome ; Uterine Hemorrhage - chemically induced ; ZK 98</subject><ispartof>Human reproduction (Oxford), 1994-01, Vol.9 (1), p.57-63</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-e62f7354bf37387fd5e0dad849578017f3cd18615ca816579f3c72d1a5a9a3953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=3918711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8195352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swahn, Marja-Liisa</creatorcontrib><creatorcontrib>Kovács, László</creatorcontrib><creatorcontrib>Cekan, Sten Z.</creatorcontrib><creatorcontrib>Aedo, Ana-Rosa</creatorcontrib><creatorcontrib>Westlund, Pär</creatorcontrib><title>Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, concomitant with less antiglucocorticoid activity. The aim of the present two-centre study was to explore the abortifacient efficacy and plasma concentrations of ZK 98, 734 in women seeking abortion. A total of 96 pregnant women with amenorrhoea of &lt;49 days were treated with oral doses of 12.5, 25, 50 or 100 mg ZK 98, 734 twice daily for 4 days. The overall rate of complete abortion and continuing live pregnancies was 68 and 20% respectively, i.e. results comparable with treatment with mifepristone alone. No dose-response relationship was noted. In patients with complete abortion, signs of luteal sysfunction in terms of oestradiol and progesterone production were evident on the fourth treatment day, in contrast to patients with failures. Increased amounts of cortisol and prolactin were found during treatment both in successfully treated patients and failures, whereas aldosterone values remained unaffected. The effect on cortisol may indicate some antiglucocorticoid activity in the human. The concentrations of ZK 98, 734 in peripheral blood after 25, 50 and 100 mg twice daily for 4 days were similar. The values were slightly above 0.5μmol/l on the second day of treatment. Maximal concentrations of 0.7 μmol/l were seen on treatment day 4. Plasma concentrations of ZK 98, 734 did not differ in cases of complete abortion and failures. In conclusion, the abortifacient efficacy in relation to dose of the new antigestaged ZK 98, 734 does not essentially differ from that of mifepristone treatment alone.</description><subject>abortion</subject><subject>Abortion, Therapeutic - methods</subject><subject>Adolescent</subject><subject>Adult</subject><subject>antigestagen</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Estrenes - adverse effects</subject><subject>Estrenes - pharmacokinetics</subject><subject>Estrenes - therapeutic use</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormones - blood</subject><subject>Humans</subject><subject>Induced abortion. Therapeutic abortion</subject><subject>Medical sciences</subject><subject>Nausea - chemically induced</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Progestins - antagonists &amp; inhibitors</subject><subject>Treatment Outcome</subject><subject>Uterine Hemorrhage - chemically induced</subject><subject>ZK 98</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpVkFtLAzEQhYMotVZ_gpAHfXNrsmk2WcEHEa3agiD1QkHCNJvYtN0L2a22_95IS8GnDHPOCWc-hM4p6VKSsstyZUufzcqlL2BRd6fL3JuqC5RJFpM91Ka9hEQx42QftUmcyIjShB6io7qeERJGmbRQS9KUMx630efI-NwV0LiywKXFBvxijStvvgoo9Br_uGaKxwOcygssWO8KV1PwOehy7grTOI0nZgrfLrTBUGRYL1zhNCywsdbo5hgd2FDSnGzfDnq9vxvdPkTD5_7j7c0w0kyKJjJJbAXjvYllIixsxg3JIJO9lAtJqLBMZ6E35RokTbhIw0LEGQUOKbBwSQddb_7Vvqxrb6yqvMvBrxUl6o-a-k9NbaipLbWQP93kq-UkN9kuvcUU9LOtDnW4zvrAxtU7G0upFJQGW7Sxuboxq50Mfq4SwQRXDx9jJZ7e3gcvg74asV_EeIy9</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>Swahn, Marja-Liisa</creator><creator>Kovács, László</creator><creator>Cekan, Sten Z.</creator><creator>Aedo, Ana-Rosa</creator><creator>Westlund, Pär</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199401</creationdate><title>Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect</title><author>Swahn, Marja-Liisa ; Kovács, László ; Cekan, Sten Z. ; Aedo, Ana-Rosa ; Westlund, Pär</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-e62f7354bf37387fd5e0dad849578017f3cd18615ca816579f3c72d1a5a9a3953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>abortion</topic><topic>Abortion, Therapeutic - methods</topic><topic>Adolescent</topic><topic>Adult</topic><topic>antigestagen</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Estrenes - adverse effects</topic><topic>Estrenes - pharmacokinetics</topic><topic>Estrenes - therapeutic use</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormones - blood</topic><topic>Humans</topic><topic>Induced abortion. Therapeutic abortion</topic><topic>Medical sciences</topic><topic>Nausea - chemically induced</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Progestins - antagonists &amp; inhibitors</topic><topic>Treatment Outcome</topic><topic>Uterine Hemorrhage - chemically induced</topic><topic>ZK 98</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swahn, Marja-Liisa</creatorcontrib><creatorcontrib>Kovács, László</creatorcontrib><creatorcontrib>Cekan, Sten Z.</creatorcontrib><creatorcontrib>Aedo, Ana-Rosa</creatorcontrib><creatorcontrib>Westlund, Pär</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swahn, Marja-Liisa</au><au>Kovács, László</au><au>Cekan, Sten Z.</au><au>Aedo, Ana-Rosa</au><au>Westlund, Pär</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>1994-01</date><risdate>1994</risdate><volume>9</volume><issue>1</issue><spage>57</spage><epage>63</epage><pages>57-63</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>The antiprogestin RU 486 (mifepristone) is highly effective in inducing early abortion in women only if the compound is combined with a prostaglandin analogue. A new related antiprogestin, ZK 98, 734, has been reported in animal studies to be much more potent as an abortifacient than mifepristone, concomitant with less antiglucocorticoid activity. The aim of the present two-centre study was to explore the abortifacient efficacy and plasma concentrations of ZK 98, 734 in women seeking abortion. A total of 96 pregnant women with amenorrhoea of &lt;49 days were treated with oral doses of 12.5, 25, 50 or 100 mg ZK 98, 734 twice daily for 4 days. The overall rate of complete abortion and continuing live pregnancies was 68 and 20% respectively, i.e. results comparable with treatment with mifepristone alone. No dose-response relationship was noted. In patients with complete abortion, signs of luteal sysfunction in terms of oestradiol and progesterone production were evident on the fourth treatment day, in contrast to patients with failures. Increased amounts of cortisol and prolactin were found during treatment both in successfully treated patients and failures, whereas aldosterone values remained unaffected. The effect on cortisol may indicate some antiglucocorticoid activity in the human. The concentrations of ZK 98, 734 in peripheral blood after 25, 50 and 100 mg twice daily for 4 days were similar. The values were slightly above 0.5μmol/l on the second day of treatment. Maximal concentrations of 0.7 μmol/l were seen on treatment day 4. Plasma concentrations of ZK 98, 734 did not differ in cases of complete abortion and failures. In conclusion, the abortifacient efficacy in relation to dose of the new antigestaged ZK 98, 734 does not essentially differ from that of mifepristone treatment alone.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8195352</pmid><doi>10.1093/oxfordjournals.humrep.a138320</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0268-1161
ispartof Human reproduction (Oxford), 1994-01, Vol.9 (1), p.57-63
issn 0268-1161
1460-2350
language eng
recordid cdi_crossref_primary_10_1093_oxfordjournals_humrep_a138320
source Oxford University Press Archive
subjects abortion
Abortion, Therapeutic - methods
Adolescent
Adult
antigestagen
Biological and medical sciences
Birth control
Estrenes - adverse effects
Estrenes - pharmacokinetics
Estrenes - therapeutic use
Female
Gynecology. Andrology. Obstetrics
Hormones - blood
Humans
Induced abortion. Therapeutic abortion
Medical sciences
Nausea - chemically induced
Pregnancy
Pregnancy Trimester, First
Progestins - antagonists & inhibitors
Treatment Outcome
Uterine Hemorrhage - chemically induced
ZK 98
title Termination of early pregnancy with ZK 98, 734: pharmacokinetic behaviour and clinical effect
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A35%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Termination%20of%20early%20pregnancy%20with%20ZK%2098,%20734:%20pharmacokinetic%20behaviour%20and%20clinical%20effect&rft.jtitle=Human%20reproduction%20(Oxford)&rft.au=Swahn,%20Marja-Liisa&rft.date=1994-01&rft.volume=9&rft.issue=1&rft.spage=57&rft.epage=63&rft.pages=57-63&rft.issn=0268-1161&rft.eissn=1460-2350&rft.coden=HUREEE&rft_id=info:doi/10.1093/oxfordjournals.humrep.a138320&rft_dat=%3Cistex_cross%3Eark_67375_HXZ_7JVWKRKG_T%3C/istex_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c387t-e62f7354bf37387fd5e0dad849578017f3cd18615ca816579f3c72d1a5a9a3953%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/8195352&rfr_iscdi=true