β-Glycosidases and Diabetic Microangiopathy I. Decreases of β-Glycosidase Activities in Diabetic Rat Kidney

Deposition of PAS2-positive materials and thickening of the basement membrane in vascular lesions are characteristic findings in diabetes mellitus, suggesting altered metabolism of glycoprotein. Changes in the activities of the glycosidases, β-N-acetylglucosaminidase [EC 3.2.1.30], β-glucuronidase [...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 1976-02, Vol.79 (2), p.265-270
Main Authors: FUSHIMI, Hisako, TARUI, Seiichiro
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - metabolism
Animals
Diabetes Mellitus - chemically induced
Diabetes Mellitus - enzymology
Diabetic Angiopathies - enzymology
Galactosidases - metabolism
Glucosidases - metabolism
Glucuronidase - metabolism
Glycoside Hydrolases - metabolism
Humans
Kidney - enzymology
Male
Rats
Retinal Diseases - enzymology
Streptozocin
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Summary:Deposition of PAS2-positive materials and thickening of the basement membrane in vascular lesions are characteristic findings in diabetes mellitus, suggesting altered metabolism of glycoprotein. Changes in the activities of the glycosidases, β-N-acetylglucosaminidase [EC 3.2.1.30], β-glucuronidase [EC 3.2.1.31], β-galactosidase [EC 3.2.1.23], and β-glucosidase [EC 3.2.1.21] were measured in various organs and the serum of diabetic rats. The activities of the first three enzymes listed above were found to be much reduced in the kidney but increased in the serum. The decreased activities of β-glycosidases in the kidney may be one of the factors responsible for the pathogenesis of microangiopathy.
ISSN:0021-924X
1756-2651
DOI:10.1093/oxfordjournals.jbchem.a131066