Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature

Collagen disease are frequently associated with malignant tumors. Recently, radiotherapy combined with chemotherapy has been recommended for improving the efficacy of treatment for nasopharyngeal carcinoma. Two patients with nasopharyngeal carcinoma complicated by collagen diseases (dermatomyositis...

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Bibliographic Details
Published in:Japanese journal of clinical oncology 1996-06, Vol.26 (3), p.189-193
Main Authors: Hareyama, M, Nagakura, H, Tamakawa, M, Hyodo, K, Asakura, K, Horikoshi, T, Tanaka, S, Imai, K, Hattori, A, Oouchi, A, Shido, M, Koshiba, H, Sakata, K, Morita, K
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - radiotherapy
Carcinoma, Squamous Cell - therapy
Cisplatin - administration & dosage
Collagen Diseases - complications
Combined Modality Therapy
Female
Fistula - etiology
Fluorouracil - administration & dosage
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms - complications
Nasopharyngeal Neoplasms - radiotherapy
Nasopharyngeal Neoplasms - therapy
Pharyngeal Diseases - etiology
Pharynx - radiation effects
Radiation Injuries - diagnosis
Radiation Injuries - etiology
Radiation Tolerance
Radiotherapy - adverse effects
Retropharyngeal Abscess - etiology
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Summary:Collagen disease are frequently associated with malignant tumors. Recently, radiotherapy combined with chemotherapy has been recommended for improving the efficacy of treatment for nasopharyngeal carcinoma. Two patients with nasopharyngeal carcinoma complicated by collagen diseases (dermatomyositis in one, and Sjögren's syndrome with mixed connective tissue disease in the other) were given radiotherapy combined with chemotherapy consisting of cis-platinum and 5-fluorouracil. Following this combination therapy, both patients developed retropharyngeal abscess and ulceration of the mucosal membrane on the posterior wall of the oropharynx; there was no tumor cell involvement. Because these injuries were more severe than would have been expected from radiotherapy alone, it is recommended that special attention be paid to combination therapy in patients with nasopharyngeal carcinoma complicated by collagen disease.
ISSN:0368-2811
1465-3621
DOI:10.1093/oxfordjournals.jjco.a023206