Heterogeneity of Histiocytes in Primary Lung Cancer Stained with Anti-S100 Protein, Lysozyme and OKT 6 Antibodies

The heterogeneity of histiocytes in primary lung cancer was investigated by immunohistochemical methods using anti-Sl0O protein and anti-lysozyme anti bodies on paraffin sections and OKT-6 monoclonal antibody on frozen sections. T-zone histiocytes (Langerhans cells and their precursors stained by an...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of clinical oncology 1984-12, Vol.14 (4), p.647-657
Main Authors: FURUKAWA, TSUGIO, WATANABE, SHAW, SATO, YUICHI, KODAMA, TETSURO, NAKAJIMA, TAKASHI, SHIMOSATO, YUKIO
Format: Article
Language:English
Subjects:
Adenocarcinoma - analysis
Adenocarcinoma - pathology
Antibodies, Monoclonal
Carcinoma, Squamous Cell - analysis
Carcinoma, Squamous Cell - pathology
Histiocytes - analysis
Histiocytes - pathology
Histocytochemistry
Humans
Lung Neoplasms - analysis
Lung Neoplasms - pathology
Macrophages - analysis
Muramidase - analysis
Muramidase - immunology
S100 Proteins - analysis
S100 Proteins - immunology
Staining and Labeling
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The heterogeneity of histiocytes in primary lung cancer was investigated by immunohistochemical methods using anti-Sl0O protein and anti-lysozyme anti bodies on paraffin sections and OKT-6 monoclonal antibody on frozen sections. T-zone histiocytes (Langerhans cells and their precursors stained by anti-SlOO protein and/or OKT-6 monoclonal antibodies) heavily infiltrated tumor tissues and regional lymph nodes in cases of moderately or well-differentiated adenocarcinoma, especially in areas of papillary growth or bronchiolo-alveolar pattern. These cells were interspersed amongst tumor cells showing dendritic figures and were occasionally present in squamous cell carcinoma. However. they were seldom found in other histological types, particularly in small cell carcinoma and carcinoid tumor. The distribution of these cells was different from that of lysozyme-positive macrophages. In this connection, T-zone histiocytes were thought to have a different immunological function from that of the monocyte-macrophage series against lung cancer. The closely similar reactivity of T-zone histiocytes with anti-Sl00 protein and OKT-6 monoclonal antibodies indicated that these two markers can be employed for paraffin and frozen sections, respectively.
ISSN:0368-2811
1465-3621
1465-3621
DOI:10.1093/oxfordjournals.jjco.a039013