Intrachromosomal Exchange Aberrations Predicted on the Basis of Globular Interphase Chromosome Model

One of the key questions in understanding mechanisms of chromosome aberration production is how does interphase chromosome structure affect aberration formation. To explore this a modelling approach is presented which combines Monte Carlo simulation of both a particle track and interphase chromosome...

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Bibliographic Details
Published in:Radiation protection dosimetry 2002-01, Vol.99 (1-4), p.193-196
Main Authors: Andreev, S G, Eidelman, YuA
Format: Article
Language:English
Subjects:
Chromatids - radiation effects
Chromosome Aberrations
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 1 - radiation effects
DNA - genetics
DNA - radiation effects
Dose-Response Relationship, Radiation
Humans
Interphase
Linear Energy Transfer
Models, Genetic
X-Rays
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Summary:One of the key questions in understanding mechanisms of chromosome aberration production is how does interphase chromosome structure affect aberration formation. To explore this a modelling approach is presented which combines Monte Carlo simulation of both a particle track and interphase chromosome structure. The structural state of interphase chromosome influences a dose-effect relationship for intrachromosomal exchange aberrations (intrachanges). It is shown that intrachanges are induced frequently by both X rays and a particles if the chromosome is in the condensed globular but not in the decondensed coiled state. Truly simple intra-arm intrachanges induced by X rays are dose squared in coiled chromosomes, but exhibit linear dose dependence in globular chromosomes. Experimental data on interarm intrachanges obtained by dual arm chromosome painting are analysed by means of the technique presented. Results of analysis support the conclusion about the arms proximity of chromosome 1 in human lymphocytes.
ISSN:0144-8420
1742-3406
DOI:10.1093/oxfordjournals.rpd.a006759