Study of long non-coding RNA and mitochondrial dysfunction in diabetic rats

Diabetes mellitus (DM) is a worldwide health problem. Many factors participate in the pathogenesis of DM, including genetic, autoimmune, metabolic, dietary and environmental factors. Intact mitochondrial function is essential for prompt cellular metabolism and energy balance. Malfunctioning mitochon...

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Bibliographic Details
Published in:QJM : An International Journal of Medicine 2021-10, Vol.114 (Supplement_1)
Main Authors: Kamal, Haytham K, Moustafa, Amr S, Elayat, Wael M, Lasheen, Noha N, AbouGhalia, Azza H
Format: Article
Language:English
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Summary:Diabetes mellitus (DM) is a worldwide health problem. Many factors participate in the pathogenesis of DM, including genetic, autoimmune, metabolic, dietary and environmental factors. Intact mitochondrial function is essential for prompt cellular metabolism and energy balance. Malfunctioning mitochondria lead to disturbed glucose metabolism and therefore evolving of DM. Epigenetics plays a role in the control of geneencoded proteins of mitochondrial function and dynamics. One of the primary epigenetic effectors is a family of long non-coding RNAs. The role of lncRNA, H19 in the regulation of mitochondrial dynamics has been recently investigated.
ISSN:1460-2725
1460-2393
DOI:10.1093/qjmed/hcab088.003