A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference

To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. Subjects were genotyped using polymerase chain reaction. Subjects with defined diurnal preference as determined by the Horne-Ostberg questionnaire and patients with delayed sl...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2003-06, Vol.26 (4), p.413-415
Main Authors: ARCHER, Simon N, ROBILLIARD, Donna L, SKENE, Debra J, SMITS, Marcel, WILLIAMS, Adrian, ARENDT, Josephine, VON SCHANTZ, Malcolm
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Choice Behavior
Circadian Rhythm - genetics
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genotype
Humans
Male
Nuclear Proteins - genetics
Period Circadian Proteins
Polymorphism, Genetic - genetics
Sleep Disorders, Circadian Rhythm - genetics
Surveys and Questionnaires
Transcription Factors
Citations: Items that cite this one
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Description
Summary:To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. Subjects were genotyped using polymerase chain reaction. Subjects with defined diurnal preference as determined by the Horne-Ostberg questionnaire and patients with delayed sleep phase syndrome. The Per3 polymorphism correlated significantly with extreme diurnal preference, the longer allele associating with morningness and the shorter allele with eveningness. The shorter allele was strongly associated with the delayed sleep phase syndrome patients, 75% of whom were homozygous. The length of the Per3 repeat region identifies a potential genetic marker for extreme diurnal preference.
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/26.4.413