Natural Anthraquinone Emodin May Protect Immune and Gastrointestinal Health During Chemotherapy Treatment

The clinical utility of 5‐fluorouracil (5FU) chemotherapy remains hampered by hematopoietic and gastrointestinal toxicities. Emodin, a natural anthraquinone, has been shown to have anti‐inflammatory potential and may be an effective complementary therapeutic. The purpose of this study was to investi...

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Published in:The FASEB journal 2020-04, Vol.34 (S1), p.1-1
Main Authors: Sougiannis, Alexander T., Vanderveen, Brandon N., Kelley, Brittany, Enos, Reilly T., Velazquez, Kandy T., Chatzistamou, Ioulia, Nagarkatti, Mitzi, Fan, Daping, Murphy, E. Angela
Format: Article
Language:English
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Summary:The clinical utility of 5‐fluorouracil (5FU) chemotherapy remains hampered by hematopoietic and gastrointestinal toxicities. Emodin, a natural anthraquinone, has been shown to have anti‐inflammatory potential and may be an effective complementary therapeutic. The purpose of this study was to investigate the ability of emodin to reduce non‐specific toxicities, especially inflammation, associated with 5FU treatment. We evaluated acute and chronic exposure to 5FU utilizing tumor‐free mice. In the chronic phase, we randomized male C57BL/6 mice into four groups; Control + Vehicle (n=10), Control + Emodin (n=10), 5FU + Vehicle (n=15), 5FU + Emodin (n=15). 5FU was administered via I.P. for 3 cycles (5 consecutive days of 5FU at 35mg/kg followed by 9 days of recovery). Emodin was administered via oral gavage 3x/week at 40mg/kg throughout the entire 3 cycles of 5FU treatment. 5FU + Emodin treated mice showed improved grip strength (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.2020.34.s1.00520