Aerobic Training Improves Hypertensive‐Myocardium Mitochondria

• Published in: The FASEB journal 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.04381
• Main Authors: Godoy Coto, Joshua, Pereyra, Erica, Cavalli, Fiorella, Caldiz, Claudia, Yeves, Alejandra, Ennis, Irene
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.2021.35.S1.04381

Essential hypertension develops a maladaptive cardiac remodeling that alters myocardial ultrastructure and induces mitochondrial dysfunction. On the other hand, aerobic training promotes a beneficial adaptive remodeling improving the heart phenotype and function. Both signaling pathways converge in the mitochondria affecting the cell fate, as they play a critical role in heart function, homeostasis, and bioenergetics. Despite this, the intracellular adaptations triggered by aerobic training on hypertensive‐myocardium mitochondria are not fully understood. Objective . To determine whether swimming training improves myocardial mitochondrial array, dynamics, and function in spontaneously hypertensive rats (SHR). Methods . 3‐month‐old male SHR were randomized to sedentary (Sed) or trained (Swim) groups. After an 8‐week (5 days/week) swimming protocol, the hearts were destined to transmission electron microscopy (TEM) imaging, RT‐PCR analysis, or mitochondrial isolation. Results are presented as mean ± SEM, except TEM data as median (IQR), and considered statistically different when p