Endothelial Cell Heterogeneity Between Conduit and Resistance Mesenteric Arteries

The vascular endothelium contains morphologically similar cells throughout, but individual cells along the length of a single vascular tree or in different regional circulations function quite differently. When observations made in large arteries are extrapolated to explain the function of endotheli...

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Bibliographic Details
Published in:The FASEB journal 2022-05, Vol.36 (S1), p.n/a
Main Authors: Morin, Emily E., Gonzalez Bosc, Laura, Kanagy, Nancy L., Naik, Jay S.
Format: Article
Language:English
Online Access:Get full text
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Summary:The vascular endothelium contains morphologically similar cells throughout, but individual cells along the length of a single vascular tree or in different regional circulations function quite differently. When observations made in large arteries are extrapolated to explain the function of endothelial cells (EC) in the resistance vasculature/microcirculation, only a fraction of these observations are consistent between artery sizes. To what extent EC from different arteriolar segments of the same tissue are phenotypically different at the single‐cell level remains unknown. Therefore, single‐cell RNA‐seq was performed using a 10X Genomics Chromium system. Cells were enzymatically digested from large (>300 µm) and small (
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.2022.36.S1.0R849