Fluoxetine inhibits arginine vasopressin (AVP)‐stimulated water permeability in rat inner medullary collecting duct (IMCD) via alpha‐2 mechanism

Fluoxetine is widely used as an anti‐depressant drug that inhibits reuptake of serotonin. The drug also induces hyponatremia by an unknown mechanism. Evidence shows that fluoxetine does not promote the release of vasopressin that would lead to hyponatremia (Marar IE and Amico JA, Endocrine, 8: 13–18...

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Bibliographic Details
Published in:The FASEB journal 2006-03, Vol.20 (5), p.A1221-A1221
Main Authors: Rouch, Al, Kudo, Lucia
Format: Article
Language:English
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Summary:Fluoxetine is widely used as an anti‐depressant drug that inhibits reuptake of serotonin. The drug also induces hyponatremia by an unknown mechanism. Evidence shows that fluoxetine does not promote the release of vasopressin that would lead to hyponatremia (Marar IE and Amico JA, Endocrine, 8: 13–18, 1998). Effects of fluoxetine on renal physiology are not known. The purpose of this study was to determine if fluoxetine affects water permeability in the IMCD. Terminal IMCDs from male Wistar rats were isolated and perfused via standard methods. To measure osmotic water permeability (Pf, μm/sec), bath fluid was hypertonic to luminal fluid (545 vs 300 mOsm/Kg H2O). Agents were added to the bath – AVP at 220 pM and fluoxetine at 2.5 μM. In one set of experiments (n=4), fluoxetine reduced AVP‐stimulated Pf from 1235±135 to 587±220 (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.20.5.A1221-a