Proteasome activity declines in aged macrophages

The ubiquitin‐proteasome pathway is involved in regulation of a variety of biologically important processes including antigen presentation by macrophages (Mφ). Age‐related decrease in proteasome activity has been reported in other tissues. However, the effect of aging on the ubiquitin‐proteasome pat...

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Bibliographic Details
Published in:The FASEB journal 2006-03, Vol.20 (5), p.A983-A983
Main Authors: Cui, Xuelin, Shang, Fu, Wu, Dayong, Meydani, Simin Nikbin
Format: Article
Language:English
Online Access:Get full text
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Summary:The ubiquitin‐proteasome pathway is involved in regulation of a variety of biologically important processes including antigen presentation by macrophages (Mφ). Age‐related decrease in proteasome activity has been reported in other tissues. However, the effect of aging on the ubiquitin‐proteasome pathway in Mφ has not been systematically studied. Thioglycollate‐elicited Mφ from young (4–6 mo) and Old (24–26 mo) male C57BL/6NIA mice were collected by lavage. Mφ from old mice exhibited significantly lower activity of all three proteasome peptidases [chymotrypsin‐like activity (young vs old, Mean ± SE): 100 ± 13 vs 62 ± 4, p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.20.5.A983-b