Increased susceptibility to myocardial ischemia and reperfusion injury in type I diabetes mellitus is mannose‐binding lectin dependent

Diabetic patients have an increased incidence of acute myocardial infarction and subsequent mortality. Mannose binding lectin (MBL)‐dependent activation of the lectin complement pathway has been shown to play a critical role in non‐diabetic myocardial ischemia‐reperfusion (MI/R) injury; therefore, w...

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Bibliographic Details
Published in:The FASEB journal 2007-04, Vol.21 (5), p.A11-A11
Main Authors: Busche, Marc Nicolai, Walsh, Mary C., Stahl, Gregory L.
Format: Article
Language:English
Online Access:Get full text
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Summary:Diabetic patients have an increased incidence of acute myocardial infarction and subsequent mortality. Mannose binding lectin (MBL)‐dependent activation of the lectin complement pathway has been shown to play a critical role in non‐diabetic myocardial ischemia‐reperfusion (MI/R) injury; therefore, we investigated the role of MBL in diabetic MI/R injury. In streptozotocin (STZ)‐induced type I diabetic mice, ejection fraction (EF) was decreased by 19% (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.5.A11