A combination nutritional therapy of psyllium (PSY) and plant sterols (PS) reduced plasma LDL‐C concentrations in hypercholesterolemic subjects by decreasing cholesteryl ester protein (CETP) activity and upregulating the LDL receptor

We previously demonstrated that a diet therapy involving consumption of 7.28 g PSY and 2 g of PS per day resulted in reductions in LDL‐C from 139.6 ± 27 to 119.8 ± 30.1 mg/dL (P < 0.01) in addition to decreases in the number of IDL particles and the smaller LDL subfractions in hypercholesterolemi...

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Bibliographic Details
Published in:The FASEB journal 2007-04, Vol.21 (5), p.A156-A156
Main Authors: Shrestha, Sudeep, Freake, Hedley C, McGrane, Mary M, Fernandez, Maria Luz
Format: Article
Language:English
Online Access:Get full text
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Summary:We previously demonstrated that a diet therapy involving consumption of 7.28 g PSY and 2 g of PS per day resulted in reductions in LDL‐C from 139.6 ± 27 to 119.8 ± 30.1 mg/dL (P < 0.01) in addition to decreases in the number of IDL particles and the smaller LDL subfractions in hypercholesterolemic individuals (n=33). The study design was a randomized double blind crossover in which the subjects consumed either 2 test cookies containing the PSY‐PS or 2 placebo cookies for 1 month. After a 3‐wk wash out period, they crossed over to the alternate treatment. Intake of the PSY‐PS cookie resulted in decrease in cholesterol concentration in LDL‐1 and LDL‐2 from 95.6 ± 25.5 and 24.6 ± 9.3 (mg/dL) to 88.2 ± 18 and 21 ± 10.3 (mg/dL) respectively (P
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.5.A156-b