Characterization of the endothelial progenitor cell

Endothelial progenitor cells (EPCs) are a subset of cells from the bone marrow that can be mobilized into the peripheral blood in response to tissue ischemia or traumatic injury. EPCs have been observed to migrate to sites of inflammation and vascular injury where they differentiate into mature endo...

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Bibliographic Details
Published in:The FASEB journal 2007-04, Vol.21 (5), p.A381-A381
Main Authors: Heine, Heather L, McManus, Bruce
Format: Article
Language:English
Online Access:Get full text
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Summary:Endothelial progenitor cells (EPCs) are a subset of cells from the bone marrow that can be mobilized into the peripheral blood in response to tissue ischemia or traumatic injury. EPCs have been observed to migrate to sites of inflammation and vascular injury where they differentiate into mature endothelial cells. It has only recently become apparent that circulating EPCs may reflect the functional state of the endothelium. Recent literature has many reports of EPC quantification in vivo by both flow cytometry and various culture systems. Agreement on the specific markers or culture assay techniques truly defining EPCs is lacking. We will, for the first time, investigate the relative overlap of EPC surface markers commonly employed in EPC analysis by multicolor flow cytometry. We have begun to investigate these EPC subsets and their relative angiogenic potential after growth in various culture systems. The results of this analysis will be the most thorough characterization of the EPC to date.
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.5.A381