Uroguanylin Relaxes Human Corpus Cavernosum and is Potentiated by Vardenafil

Uroguanylin (UGN) is a peptide shown to stimulate membrane bound guanylate cyclase receptors (GC) which has been identified in human corpora cavernosa (HCC). This study tests whether UGN induces HCC relaxation and evaluate its interaction with soluble GC. Strips of HCC were preconstricted with pheny...

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Bibliographic Details
Published in:The FASEB journal 2007-04, Vol.21 (5), p.A433-A433
Main Authors: Fonteles, Manassés Claudino, Sousa, Clauber Mota, Cerqueira, João Batista Gadelha, Batista, Francisco José Arnaud, Santos, Cláudia Ferreira, Silva, Lúcio Flávio Gonzaga, Nascimento, Nilberto Robson Falcão
Format: Article
Language:English
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Summary:Uroguanylin (UGN) is a peptide shown to stimulate membrane bound guanylate cyclase receptors (GC) which has been identified in human corpora cavernosa (HCC). This study tests whether UGN induces HCC relaxation and evaluate its interaction with soluble GC. Strips of HCC were preconstricted with phenylephrine (PHE) and concentration‐response curves (10−10 to 10−5 M) to human UGN were performed. In other experimental set tissues were treated with 10−7 M vardenafil 10 min before PHE challenge. UGN effects were evaluated after 10−4M L‐NAME or ODQ and also compared with atrial natriuretic peptide (ANP). UGN induced maximal relaxation of 55 ± 7.5 % (PD2 7.4) when used alone and 82.6 ± 4.5% (PD2 14.1) (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.5.A433-a