The role of zinc (Zn) and metallothionein (MT) in dextran sulfate sodium (DSS)‐induced colitis in MT‐null (MT−/−) and wild‐type mice

Introduction: Zinc (Zn) and its binding protein metallothionien (MT) have been proposed to suppress the disease activity of ulcerative colitis. The aim of the present is to determine the role of Zn and MT in the dextran sulfate sodium (DSS)‐induced model of colitis in mice. Methods: A DSS dose‐respo...

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Bibliographic Details
Published in:The FASEB journal 2007, Vol.21 (6), p.A1120-A1120
Main Authors: Tran, Cuong D, Ball, Joanne, Sundar, Swagatha, Howarth, Gordon S
Format: Article
Language:English
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Summary:Introduction: Zinc (Zn) and its binding protein metallothionien (MT) have been proposed to suppress the disease activity of ulcerative colitis. The aim of the present is to determine the role of Zn and MT in the dextran sulfate sodium (DSS)‐induced model of colitis in mice. Methods: A DSS dose‐response study was conducted in male C57BL/6 wild‐type (MT+/+) and MT‐null (MT−/−) mice by supplementing 2%, 3% and 4% DSS in the drinking water for 6 d. In the intervention study, colitis was induced by 2% DSS, Zn (24 mg/ml as ZnO) was gavaged (0.1 ml) daily, concurrent with DSS administration, and the disease activity index (DAI) scored daily. Histology, MT levels and myeloperoxidase (MPO) activity were determined. Results: DAI was increased (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.6.A1120-c