Intima‐media thickness in Ladakh highlanders

In animal models and humans, chronic intermittent hypoxia increases subclinical atherosclerosis. High animal fat diets and hypertension are also risk factors for arterial disease. Noninvasive ultrasound permits measurements of intima‐media thickness (IMT) in the human carotid artery. This measure is...

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Bibliographic Details
Published in:The FASEB journal 2007, Vol.21 (6), p.A947-A947
Main Authors: Watson, Rebecca R, Greene, E R, Prisman, E, Slessarev, M, Ito, S, Norboo, T, Stobdan, T, Diskit, D, Norboo, A, Kunzang, M, Fisher, J A, Appenzeller, O
Format: Article
Language:English
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Summary:In animal models and humans, chronic intermittent hypoxia increases subclinical atherosclerosis. High animal fat diets and hypertension are also risk factors for arterial disease. Noninvasive ultrasound permits measurements of intima‐media thickness (IMT) in the human carotid artery. This measure is a surrogate for subclinical atherosclerosis. We measured common carotid artery IMT in 96 (20 female) geographically, perhaps genetically, isolated native highlanders from Korzok, India (4550 m). This population has a high animal fat consumption and a high prevalence of hypertension. They also have normal BMIs and high daily aerobic work loads. Data are mean (SD): The linear regression equation relating age to IMT was IMT = 0.006(Age) + 0.24 (r=0.74, p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.6.A947-a