Relationship between exercise energy expenditure and telomere length and telomerase activity

Shortened telomere length and decreased telomerase activity have recently been associated with perceived psychological stress and cardiovascular disease risk factors. The purpose of this study was to examine the relationship between exercise energy expenditure (EEE) and telomere length and telomeras...

Full description

Saved in:
Bibliographic Details
Published in:The FASEB journal 2007, Vol.21 (6), p.LB108-LB108
Main Authors: Ludlow, Andrew T, Zimmerman, Jo B, Hearn, Joseph W, Witkowski, Sarah, Hatfield, Bradley D, Roth, Stephen M
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Shortened telomere length and decreased telomerase activity have recently been associated with perceived psychological stress and cardiovascular disease risk factors. The purpose of this study was to examine the relationship between exercise energy expenditure (EEE) and telomere length and telomerase activity. Thirty‐eight male (n = 20) and female (n = 18) participants 50–70 yr. were assessed for weekly EEE level using the exercise component of the Yale Physical Activity Survey. Lifetime consistency of EEE was also determined. Subjects were recruited across a range of EEE levels and grouped into tertiles according to EEE (0–1000, 1001–3500, and >3500 Kcal/wk). Relative telomere length and telomerase activity were measured in peripheral blood mononuclear cells (PBMCs). After covarying for BMI, perceived psychological stress, and sex, relative telomere length was significantly higher in the moderate EEE group compared to both the low and high EEE groups (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.21.6.LB108-d