Effects of Long‐Term Feeding of D‐psicose on Gene Expressions of Rat Liver and Skeletal Muscle

• Published in: The FASEB journal 2007, Vol.21 (6), p.LB59-LB59
• Main Authors: Shirai, Yoko, Matsuo, Tatsuhiro, Yagi, Kanako, Uchida, Yoshiyuki, Izumori, Ken
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.21.6.LB59-c

Previous studies have shown that dietary D‐psicose decrease body fat accumulation and increase liver glycogen in consequence of serum glucose decline and serum insulin elevation. To evaluate in detail we measured gene expression of liver and skeletal muscle in rats after long‐term feeding of D‐psicose. Thirty‐six male Wistar rats were divided into four groups. Each group except for the control group was fed a diet of 5% D‐fructose, D‐psicose, or psico‐rare sugar (1:1 mixture of D‐fructose and D‐psicose) for 3‐8 weeks. Within 7weeks of D‐psicose intake showed no significant change to diurnal variation in plasma glucose and insulin levels. Lower plasma insulin levels and higher liver glycogen contents were observed in the psicose group than in the other groups after 8 weeks feeding of experimental diet. In the liver, GLUT2 and glucokinase mRNA expression markedly increased in the psicose group than in the other groups. No significant changes in GLUT4 and LKB1 expression of gastrocnemius muscle were measured. Theses results suggest that improvements of serum and liver component by dietary D‐psicose were partly influenced by alteration of hepatic gene expressions. Therefore these changes of serum and liver component require at least 8weeks feeding of D‐psicose.