Three‐day fasting limits reperfusion ventricular arrhythmias

In ischemic tissues, the oxidation of NADH to NAD+ is impaired. This constitutes the conditions of the reductive stress. Then, higher rates of reactive oxygen species production can be observed. Fasting before exposure to ischemia should increase ketogenesis, which consumes NADH and thus eliminates...

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Bibliographic Details
Published in:The FASEB journal 2008-04, Vol.22 (S2), p.50-50
Main Authors: Snorek, Michal, Hodyc, Daniel, Neckar, Jan, Tousek, Frantisek, Wilhelm, Jiri, Kolar, Frantisek, Herget, Jan
Format: Article
Language:English
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Summary:In ischemic tissues, the oxidation of NADH to NAD+ is impaired. This constitutes the conditions of the reductive stress. Then, higher rates of reactive oxygen species production can be observed. Fasting before exposure to ischemia should increase ketogenesis, which consumes NADH and thus eliminates the reductive stress. We investigated whether the three‐day fasting affects the incidence and severity of ventricular arrhythmias occurring during myocardial ischemia and reperfusion in adult male Wistar rats. Anesthetized open‐chest animals were subjected to 20‐min left anterior descending coronary artery occlusion followed by reperfusion. A single‐lead electrocardiogram was recorded and arrhythmias were assessed according to the Lambeth Conventions. Fasting did not affect ischemic arrhythmias: neither the number of premature ventricular complexes (PVCs) nor the total duration of ventricular tachycardia (VT) differed between fasting and control groups. The number of PVCs during early reperfusion phase was significantly (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.22.2_supplement.50