Effects of Oligonol Supplementation on the Appearance of Skin Photo‐aging, Wrinkles, Hyperpigmrntation and Lentigines

• Published in: The FASEB journal 2010-04, Vol.24 (S1), p.lb319-lb319
• Main Authors: Fujii, Hajime, MacKenzie, Albert R., Kitadate, Kentaro
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.24.1_supplement.lb319

Research has documented the oligomerized flavonoid Oligonol's positive effects on oxidative stress prevention, signal transduction, blood circulation and metabolic syndrome. This may result in skin improvement due to changes in endothelial function and cytokine profiles. We conducted a three month clinical pilot study in the United States to evaluate the effects of the oral supplementation of Oligonol on the appearance of skin photo‐aging, wrinkling, hyperpigmentation and lentigines. The outcome (n=eleven), confirmed known positive effects and the discovery of other possible effects: (A) Six subjects showed improvement in CRP levels, a marker for in vivo inflammation, IL‐6 and other cytokines. (B) Cross‐polarized DermLite® photographs showed a decrease in fine lines on eight subjects. Deeper wrinkles were lessened in two subjects. (C) There was a consistent overall lightening and brightening of complexion, less redness and blotchiness, fading of freckles and brown pigmented blotches. (D) Optical profilometry on skin molds supported subjective and observer noted improvement of fine lines in two cases. (E) Three subjects noted that their hair felt thicker, believed they had more hair and noted new hair growth along their hairline. (F) Positive results were noted on participants’ final questionnaire on overall health including mental functioning. Study research sponsor is Amino Up Chemical Co., Ltd.