Synergistically protective effect of melatonin on exercise‐induced neurological recovery in the spinal cord injured rats

Nitric oxide (NO) may aggravate neuronal injury after spinal cord injury (SCI). We hypothesized that NO produced by inducible nitric oxide (iNOS) accelerates secondary damage to spinal tissue, which may be reversed by a neuroprotectant, melatonin. This study investigated the effects of combination t...

Full description

Saved in:
Bibliographic Details
Published in:The FASEB journal 2010-04, Vol.24 (S1), p.lb415-lb415
Main Authors: Park, Kanghui, Park, Sookyoung, Palaksha, KJ, Hong, Yonggeun
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nitric oxide (NO) may aggravate neuronal injury after spinal cord injury (SCI). We hypothesized that NO produced by inducible nitric oxide (iNOS) accelerates secondary damage to spinal tissue, which may be reversed by a neuroprotectant, melatonin. This study investigated the effects of combination therapy with melatonin (10mg/kg) and exercise (10m/min) on the recovery of SCI caused by contusion. We examined locomotor recovery, iNOS gene expression as well as autophagic, apoptotic signaling, including Beclin‐1, LC3, p53, IKK¥á protein expression, and histological alterations of ventral horn. Melatonin‐treated exercise resulted in a significant increased hindlimb movement (P
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.24.1_supplement.lb415