Tocotrienol and Growth Factors In Acute Gasrtic Mucosal Injury

• Published in: The FASEB journal 2010-04, Vol.24 (S1), p.lb475-lb475
• Main Authors: Ismail, Nafeeza Mohd, Saad, Qodriyah M, Yusoff, Yasmin A
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.24.1_supplement.lb475

Gastric mucosal damage caused by nonsteroidal anti‐inflammatory drugs is recognized as the most serious adverse reaction for this drug class and has been the stimulus for research aimed at developing more effective gastroprotective drugs. Transforming growth factor alpha (TGFa) and epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) are crucial in the regulation for reconstruction of damaged mucosal structures. We have previously shown that tocotrienol (T3) improved NSAID‐induced AGML. The present study aims to assess the effect of pretreatment of rats, exposed to a single dose of NSAID on the expression of growth factors, with T3. After 8 weeks, they were administered with a single dose of indomethacin. Six hours post insult, measurements of TGF‐α, bFGF, EGF‐R and ERK‐1 were done. There was a significant increase in the TGF‐α, bFGF, EGF‐R and ERK‐1 content the gastric mucosa of rats treated with T3 but not in rats without T3. This findings demonstrated that T3 rapidly stimulated the growth factors involved in cell proliferation and migration through involvement of EGF‐R‐ MAP and Erk1 kinase. We conclude T3 may potentially accelerate healing of AGML through higher expression of growth factors, related receptor and kinase involved in gastric mucosal repair. Source of research fund: Ministry of Science, Technology and Innovation, Malaysia IRPA 06‐02‐02‐0052‐ EA246.