Synthesis of Some New 3‐(Heteroaryl‐iminoethyl)‐Benzopyran‐2‐ones and their Antimicrobial Activity

• Published in: The FASEB journal 2011-04, Vol.25 (S1), p.lb383-lb383
• Main Authors: Hoti, Ramiz, Mulliqi‐Osmani, Gjyle, Vehaoi, Idriz, Thaçi, Veprim, Gashi, Fatbardh, Ismaili, Hamit
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.25.1_supplement.lb383

Novel 3‐(heteroaryl‐iminoethyl)‐benzopyran‐2‐ones are synthesized by catalytic condensation of 3‐acetyl‐benzopyran‐2‐one and corresponding heteroarylamines. Condensation of 3‐acetyl‐benzopyran‐2‐one 1 and 2‐aminothiazoles 2(a,b) gave corresponding 3‐[(thiazol‐2‐ylimino)‐ethyl]‐benzopyran‐2‐ones 3(a,b). By catalytic condensation of 3‐acetyl‐benzopyran‐2‐one 1 and 3‐amino‐5‐methylthio‐1H‐1,2,4‐triazol 2c, 3‐[1‐(5‐methylthio‐1,2,4‐triazol‐3‐ylimino)‐ethyl]‐benzopyran‐2‐one 3c was synthesized, whereas condensation of 1 and 3‐amino‐5,6‐dimethyl‐1,2,4‐triazine 2d gave 3‐[1‐(5,6‐dimethyil‐triazine‐3‐ylimino)‐ethyl]‐benzopyran‐2‐one 3d. The antimicrobial activity of products 3(a–d) were investigated and results were submitted for their activities against E. coli, S. aureus and Candida albicans. Compound 3c showed light bactericide activity against S. aureus. Emphatic activity against E. coli exhibited compounds 3a and 3b, whereas 3d and 3c exhibited the strongest activity against Candida albicans. In general there was a direct positive correlation between increasing concentration of the compound and antimicrobial activity.