The tryptophan hydroxylase 2 (Tph2) polymorphism C2432T mediates wound repair and behavioral responses to SSRIs in a sex‐specific manner

Abstract only Current therapies for Major Depressive Disorder involve manipulation of brain monoamine systems, but mechanisms behind successful treatment responses remain unclear. We examined whether a novel polymorphism C2432T in the Tph2 gene mediates differences in wound repair and response to ci...

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Bibliographic Details
Published in:The FASEB journal 2012-04, Vol.26 (S1)
Main Authors: Brookshire, Bethany, Hill-Smith, Tiffany E., Balu, Darrick T, Turner, Jill, Blendy, Julie A, Lucki, Irwin
Format: Article
Language:English
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Summary:Abstract only Current therapies for Major Depressive Disorder involve manipulation of brain monoamine systems, but mechanisms behind successful treatment responses remain unclear. We examined whether a novel polymorphism C2432T in the Tph2 gene mediates differences in wound repair and response to citalopram between two mouse strains, MRL/MpJ (MRL; antidepressant‐responding) compared to C57Bl/6J (C57; antidepressant‐nonresponding) (Balu et al, 2009, Clark et al, 1998). We cross‐bred the MRL and C57 strains for two generations to isolate C2432T and determine functionality using wound closure and the behavioral response to SSRIs in the tail suspension test (TST). MRL mice showed an enhanced wound healing response (p
ISSN:0892-6638
1530-6860
DOI:10.1096/fasebj.26.1_supplement.lb508