Increased waist circumference is associated with increased malondialdehyde and decrease of adiponectin in women with Metabolic Syndrome

• Published in: The FASEB journal 2013-04, Vol.27 (S1)
• Main Authors: Talon, Lidiana Camargo, Oliveira, Claudia Diniz Lopes, Pierine, Damiana Tortolero, Nunes, Vania Santos, Okoshi, Marina Politi, Correa, Camila Renata
• Format: Article
• Language: English
• ISSN: 0892-6638; 1530-6860
• DOI: 10.1096/fasebj.27.1_supplement.lb326

Abstract only The aim of the study was to correlate waist circumference (WC) with oxidative stress (OS) and production of adiponectin. We included 15 healthy women (HW) and 15 women with MS, aged between 18 and 50 years old. To confirm the diagnosis of MS the following parameters were determined: WC, HDL, triglycerides (TG), blood glucose, systolic blood pressure (SBP), diastolic blood pressure (DBP). We also performed a body mass index (BMI), leptin, adiponectin and malondialdehyde (MDA). Statistical analyzes were performed by Student's t test and Pearson's correlation. The MS group presented increased BMI, WC, TG, blood, leptin, DBP, MDA and lower values for HDL and adiponectin. There was negative correlation between WC and adiponectin (r = −0.56156, p = 0.0012) and positive correlation between MDA and WC (r = 0.45913 and p = 0.0107) and leptin and glucose (r = 0.52735, p = 0.0027). We can conclude that abdominal obesity leads to increased OS and a decrease in adiponectin and this can lead to cardiovascular disease. Financial Support: CNPq, FAPESP 2011/08373–5