Disulfiram-Like Reactions With Newer Cephalosporins: Cefmenoxime

A 54-year-old woman with recurrent adenocarcinoma of the uterus was treated with new third-generation cephalosporin, cefmenoxime. for a urinary tract infection. She received an alcohol-containing tylenol elixir while receiving the drug on two occasions. A disulfiram-like reaction was noticed each ti...

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Bibliographic Details
Published in:The American journal of the medical sciences 1984-04, Vol.287 (2), p.45-47
Main Authors: Kannangara, D.W., Gallagher, Katherine, Lefrock, J.L.
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - adverse effects
Alcohol
Biological and medical sciences
Cefmenoxime
Cefotaxime - adverse effects
Cefotaxime - analogs & derivatives
Cefotaxime - pharmacology
Cephalosporins
Disulfiram
Disulfiram - pharmacology
Drug Interactions
Drug toxicity and drugs side effects treatment
Ethanol - pharmacology
Female
Humans
Medical sciences
Methyltetrazolethiol
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Third generation cephalosporins
Urinary Tract Infections - drug therapy
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Summary:A 54-year-old woman with recurrent adenocarcinoma of the uterus was treated with new third-generation cephalosporin, cefmenoxime. for a urinary tract infection. She received an alcohol-containing tylenol elixir while receiving the drug on two occasions. A disulfiram-like reaction was noticed each time. Such reactions have been described in patients receiving certain drugs such as 5-nitroimidazoles, nitrofurans, sulfonylureas and certain newer cephalosporins with a methyltetrazolethiol side chain. This is the first report of a disulfiram-like reaction with cefmenoxime. The mechanism, causes, and significance of disulfiram-like reactions are discussed.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198403000-00012