The Alpha2-Adrenergic System of the Platelet in Cystic Fibrosis

The ability of norepinephrine to inhibit prostaglandin E1 (PGE1)-stimulated accumulation of adenosine 3′:5′ cyclic monophosphate (cyclic AMP) in intact washed platelets was determined in 12 patients with cystic fibrosis, 6 parents of patients with cystic fibrosis, and a total of 21 healthy age-match...

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Bibliographic Details
Published in:The American journal of the medical sciences 1984-10, Vol.288 (3), p.104-108
Main Authors: Davis, Pamela B., Dieckman, Lynda, Boat, Thomas F., Stern, Robert C., Doershuk, Carl F.
Format: Article
Language:English
Subjects:
Alpha-adrenergic receptor
Biological and medical sciences
Cystic fibrosis
Gastroenterology. Liver. Pancreas. Abdomen
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
Platelets
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Summary:The ability of norepinephrine to inhibit prostaglandin E1 (PGE1)-stimulated accumulation of adenosine 3′:5′ cyclic monophosphate (cyclic AMP) in intact washed platelets was determined in 12 patients with cystic fibrosis, 6 parents of patients with cystic fibrosis, and a total of 21 healthy age-matched controls. Patients with cystic fibrosis and their parents did not differ from their age-matched controls in basal or PGE1-stimulated levels of cyclic AMP, nor in the dose dependent inhibition of cAMP accumulation by norepinephrine. Moreover, binding sites for [3H]-dihydroergocryptine were present in normal numbers and had normal ligand affinity in platelet membranes from patients with cystic fibrosis. In all measures tested, the alpha2-adrenergic system in the platelet was normal in cystic fibrosis.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198410000-00002