Case Report: Prolonged Vancomycin-Associated Neutropenia in a Chronic Hemodialysis Patient

A chronic hemodialysis patient developed severe marrow granulocytic hypoplasia and peripheral blood neutropenia related to vancomycin therapy for an infected arteriovenous fistula. Neutropenia was prolonged and associated with sustained serum levels of vancomycin that persisted for more than 4 weeks...

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Bibliographic Details
Published in:The American journal of the medical sciences 1987-08, Vol.294 (2), p.110-113
Main Authors: Milsteen, Scott, Welik, Robert, Heyman, Meyer R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Hemodialysis
Medical sciences
Neutropenia
Pharmacology. Drug treatments
Toxicity: blood
Vancomycin
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Summary:A chronic hemodialysis patient developed severe marrow granulocytic hypoplasia and peripheral blood neutropenia related to vancomycin therapy for an infected arteriovenous fistula. Neutropenia was prolonged and associated with sustained serum levels of vancomycin that persisted for more than 4 weeks following the last dose of vancomycin. No vancomycin-dependent leukoagglutinins were demonstrable in the patient’s serum. Although a direct toxic effect on marrow granulocyte production seems likely, a vancomycin-dependent immune suppression of granulopoiesis cannot be ruled out.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198708000-00010